David R. Bundle

Refereed Publications

205 O’Reilly, M. K., Collins, B. E., Han, S., Liao, L., Rillahan, C. Kitov, P. I., Bundle, D. R., and Paulson, J. C. Bi-functional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells. J. Am. Chem. Soc., in press, accepted 17th April 2008.

204 Wu, X., Lipinski, T., Paszkiewicz, E., and Bundle, D. R. Synthesis and Immunochemical characterization of S-linked glycoconjugate vaccines against Candida albicans
Chem. Eur. J., in press, 2008, 10.1002/chem.200800352.

203 Dziadek, S., Jacques, S. and Bundle, D. R. A novel linker methodology for the synthesis of tailored conjugate vaccines composed of complex carbohydrate antigens and specific TH-cell peptide epitopes. Chem. Eur. J., in press, 2008, 10.1002/chem.200800065.

202 Kitov, P. I., Lipinski, T., Paszkiewicz, E., Solomon, D., Sadowska, J. M., Grant, G. G. A., Mulvey, G. L., Kitova, E. N., Klassen, J. S., Armstrong, G. D. and Bundle, D. R. An Entropically Efficient Supramolecular Inhibition Strategy for Shiga Toxins. Angew. Chemie Intl. Ed., 47, 672-676, 2008.

201 Townson, K., Greenshields, K. N., Veitch, J., Nicholl, D., Eckhardt, M., Galanina, O., Bovin, N., Samain, E., Antoine, T., Bundle, D. R., Zhang, P., Ling, C.-C., and Willison, H. J. Sulfatide binding properties of murine and human antiganglioside antibodies. Glycobiology, 17, 1156 – 1166, 2007.

200 Moore, S. L., Uitz, C., Ling, C.-C., Bundle, D. R., Fusco P. C. and Michon, F. Epitope Specificities of the Groups Y and W-135 Polysaccharides of Neisseria meningitides. Clinical and Vaccine Immunology, 14, 1311-1317, 2007.

199 Wu, X., Lipinski, T., Carrell, F., Bailey, J. J., and Bundle, D. R. Synthesis and Immunochemical Studies on a Candida albicans Clustered Glycoconjugate Vaccine. Org. Biomol. Chem., 5, 3477 – 3485, 2007.

198 Kitova, E.N., Kitov, P.I., Paszkiewicz, E., Kim, J., Mulvey, G.L., Armstrong, G.D., Bundle, D.R., and Klassen, J.S. Affinities of Shiga Toxins 1 and 2 for Univalent and Oligovalent Pk Trisaccharide Analogs Measured by Electrospray Ionization Mass Spectrometry. Glycobiology, 17, 1156-1166, 2007

197 Townson, K., Boffey, J., Nicholl, D., Veitch, J., Bundle, D.R., Zhang, P., Samain, E., Antoine, T., Bernardi, A., Arosio, D., Sonnino, S., Isaacs, N., and Willison, H.J. Solid phase immunoadsorption for therapeutic and analytical studies on neuropathy-associated anti-GM1 antibodies. Glycobiology, 17, 294–303, 2007.

196 Bundle, D.R. Nitz, M., Wu, X., and Sadowska, J.M. A uniquely small, protective carbohydrate epitope may yield a conjugate vaccine for Candida albicans. Amer. Chem. Soc., Symp. Ser., 989, 163-183, 2007.

195 Cai, Y., Ling, C.-C., and Bundle, D.R. A general, efficient and stereospecific route to sphingosine, sphinganines, phytosphingosines and their analogs. Org. Biomol. Chem., 4, 1140-1146, 2006.

194 Jacques, S., Rich, J.R., Ling, C.-C., and Bundle, D.R. Chemoenzymatic synthesis of GM3 and GM2 gangliosides containing a truncated ceramide functionalized for glycoconjugate synthesis and solid phase applications. Org. Biomol. Chem., 4, 142-154, 2006.

193 Rich, J.R., Wakarchuk, W.W., and Bundle, D.R. Chemical and chemoenzymatic synthesis of S-linked ganglioside analogues and their protein conjugates. Immunogens with improved in vivo availability? Chem. Eur. J., 12, 845-858, 2006.

192 Bundle, D.R. Rich, J.R., Jacques, S., Yu, H.N., Nitz, M., and Ling, C.-C. Thio-oligosaccharide conjugate vaccines evoke antibodies specific for native antigens. Angew. Chem. Int. Ed., 44, 7725-7729, 2005.

191 Kanda, V. Kitov, P.I., Bundle, D.R. McDeermott, M.T. Surface Plasmon Resonance Imaging Measurements of the Inhibition of Shiga-Like Toxin by Synthetic Multivalent Inhibitors. Anal. Chem. Submitted 10th March, accepted 18th August 2005.

190 Solomon, D., Kitov, P. I., Paszkiewicz, E., Grant, G. A., Sadowska, J. M.., and Bundle, D. R. Hetero-Bifunctional Multivalent Inhibitor-Adaptors Mediate Specific Aggregation between Shiga Toxin and a Pentraxin. Org. Lett., submitted June 30th 2005

189 Cai, Y., Ling, C.-C., and Bundle, D. R. A Facile Approach to 2-Acetamido-deoxy-b-D-Glucopyranosides via the Furanosyl Oxazoline, Org. Lett., submitted June 29th 2005

188 Rich, J.R., Wakarchuk, W.W., and Bundle, D.R. Chemical and Chemoenzymatic Synthesis of S-Linked Ganglioside Analogues and Their Protein Conjugates. Immunogens with Improved in vivo Availability? Chemistry a European Journal, submitted May 2005

187 Wu, X., and Bundle, D.R. Synthesis of glycoconjugate vaccines for Candida albicans using novel linker methodology. J. Org. Chem., submitted May 27

186 Ho, J.G.S., Kitov, P.I., Paszkiewicz, E., Sadowska, J., Bundle, D.R., and. Ng, K.K.-S. Ligand-assisted aggregation of proteins: dimerization of serum amyloid P component by bivalent ligands. J. Biol Chem., accepted subject to revision May 2005

185 McGavin, R.S. and Bundle, D.R. Developing high affinity oligosaccharide inhibitors: conformational pre-organization paired with functional group modification. Org. Biomol. Chem., 3, 2733 – 2740, 2005.

184 Gagne, R.A., McGavin, R.S., Chervenak, M.C. and Bundle, D.R. The design, synthesis and evaluation of high affinity macrocyclic carbohydrate inhibitors. Org. Biomol. Chem., 3, 2723 – 2732, 2005.

183 Wu, X., Ling, C.-C., and Bundle, D.R. A New Homobifunctional p-Nitro Phenyl Ester Coupling Reagent for the Preparation of Neoglycoproteins. Org. Lett., 6(24), 4407-4410, 2004.

182 Rich, J., and Bundle, D.R. S-Linked Ganglioside Analogues for Use in Conjugate Vaccines. Org. Lett., 6(6), 897-900, 2004.

181 Andersen, S., Ling, C.-C., Zhang, P., Townson, K., Willison, H.J., and Bundle, D.R. Synthesis of ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian Barré syndrome Org. Biomol. Chem., 2, 1199 – 1212, 2004.

180 Willison, H.J., Townson, K., Veitch, J., Boffey, J., Isaacs, N., Andersen, S., Zhang, P., Ling, C.-C., and Bundle, D.R. Synthetic disialylgalactose immunoadsorbents deplete anti-GQ1b antibodies from neuropathy sera. Brain., 127: 680-691, 2004.

179 Rich, J.R., Szpacenko, A., Palcic, M.M., and Bundle, D.R. Glycosyltransferase Catalyzed Synthesis of Thiooligosaccharides Angew. Chem. Int. Ed., 43(5): 613-615, 2004

178 Vyas, N.K., Vyas, M.N., Chervenak, M.C., Bundle, D.R., Pinto, B.M., and Quiocho, F.A. Structural basis of peptide-carbohydrate mimicry in an antibody-combining site. Proc. Natl. Acad. Sci (USA), 100 (25): 15023-15028, 2003.

177 Kitov, P.I. and Bundle, D.R. On the Nature of the Multivalency Effect: A Statistical Thermodynamic Model J. Am. Chem. Soc., 125: 16271-16284, 2003.

176 Yung, A.,Turnbull, B., Kalverda, A., Thompson, G., Homans, S., Kitov, P.I. and Bundle, D.R. Large scale millisecond inter-subunit dynamics in the B subunit homopentamer of the toxin derived from E. coli O157. J. Am. Chem. Soc., 125(43): 13058-13062, 2003.

175 Kmath, V., Sadowska, J., Nilar, S., Bundle, D.R., Hindsgaul, O. Synthetic analogs of the Lewis^b-tetrasaccharide and their binding to the lectin GS-IV – Part 1. Synlett, in press, 2003.

174 Kitov, P.I., Shimizu, H., Homans, S.W., and Bundle, D.R. Optimization of Tether Length in non-Glycosidically Linked Bivalent Ligands that Target Sites 2 and 1 of Shiga-like Toxin. J. Am. Chem. Soc., 125: 3284-3294, 2003.

173 Mulvey, G.L., Marcato, P., Kitov, P.I., Sadowska, J., Bundle, D.R., Armstrong, G.D. Assessment in Mice of the Therapeutic Potential of tailored, Multivalent Shiga Toxin Carbohydrate Ligands. J. Infectious Diseases, 187: 640-649, 2003

172 Kitova, E.N., Wang, W., Bundle, D.R. and Klassen, J.S. Retention of Bioactive Ligand Conformation in a Gaseous Protein-Trisaccharide Complex. J. Am. Chem. Soc., 124(47): 13980-13981, 2002.

171 Kitova, E.N., Bundle, D.R. and Klassen, J.S. Evidence for the Preservation of Specific Intermolecular Interactions in Gaseous Protein-Oligosaccharide Complexes. J. Am. Chem. Soc., 124: 9340-9341, 2002.

170 Vyas, N. K.,Vyas, M. N., Chervenak, M. C., Johnson,M. A., Pinto, B. M., Bundle, D. R., and Quiocho, F. A. Molecular Recognition of Oligosaccharide Epitopes by a Monoclonal Fab Specific for Shigella flexneri Y Lipopolysaccharide: X-ray Structures and Thermodynamics. Biochemistry 41: 13575-13586, 2002

169 D. Uhrín, A. V. K. Prasad, J.-R. Brisson and D. R. Bundle Carbohydrate-Antibody Interactions by NMR. Antibody interactions by NMR. Canad. J. Chem. 80: 904-907, 2002.

168 H. N. Yu, C.-C. Ling and D. R. Bundle Probing Carbohydrate-Antibody Interactions: Synthesis of Three Salmonella Epitopes for SPR Studies. Canad. J. Chem. 80: 1131-1140 2002.

167 T. Lowary, E. Eichler and D. R. Bundle. Oligosaccharide recognition by antibodies: synthesis and evaluation of talose oligosaccharide analogues. Canad. J. Chem. 80: 1112-1130, 2002.

166 Zhang, P., Appleton, J. A., Ling, C. C. and Bundle, D. R. Synthesis of disaccharide congeners of the Trichinella spiralis glycan and binding site mapping of two protective antibodies. Canad. J. Chem. . 80: 1141-1161, 2002.

165 Kitova, E.N., Bundle, D.R. and Klassen, J.S. Thermal Dissociation of Protein-Oligosaccharide Complexes in the Gas Phase: Mapping the Intrinsic Intermolecular Interactions. J. Am. Chem. Soc., 124, 5902-5913, 2002.

164 Soltyk, A. M., MacKenzie, C. R., Wolski, V. M., Hirama, T., Kitov, P. I., Bundle, D. R., and Brunton, J. L. A mutational analysis of the globotriaosylceramide binding sites of verotoxin VT1. J. Biol Chem., 277, 5351-5359, 2002.

163 Nitz, M., Ling, C. C., Otter, A., Cutler, J. E. and Bundle, D. R. The unique solution structure and immunochemistry of the Candida albicans β-1,2-mannopyranan cell wall antigen. J. Biol. Chem. 277, 3440-3446, 2002.

162 Appleton, J.A., Dell, A., Nitz, M., and Bundle, D.R. Novel N-glycans of the parasitic nematode Trichinella spiralis. Trends in Glycoscience and Glycotechnology, 13, 481-492 (2001).

161 Nitz, M. and Bundle, D.R. Synthesis of di- to hexasaccharide 1,2-linked β-mannopyranan oligomers, a terminal S-linked tetrasaccharide congener and the corresponding BSA glycoconjugates. J. Org. Chem., 66, 8411- 8423, 2001.

160 G. Mulvey, P.I. Kitov, P. Marcato, D.R. Bundle and G.D. Armstrong. Glycan mimicry as a basis for novel anti-infective drugs. Biochimie 83, 841-847, 2001.

159 Kitov, P.I. and Bundle, D.R. Mild oxidative one-pot allyl group cleavage. Org. Let., 3, 2835-2838, 2001.

158 Wacowich-Sgarbi, S.A., Ling, C.C., Otter, A. and Bundle, D.R. A tethered disaccharide trapped as its anti conformer calibrates the Karplus relationship for ³J_C,H coupling constants. J. Am. Chem. Soc., 123, 4362-4363, 2001.

157 Kitova, E.N., Kitov, P.I., Bundle D.R., and Klassen, J.S. The observation of multivalent complexes of Shiga-like toxin with globotrioside and the determination of their stoichiometry by nanoelectrospray Fourier-transform ion cyclotron resonance mass spectrometry. Glycobiology, 11, 605-611, 2001.

156 Kitov, P.I. and Bundle, D.R. Synthesis and structure-activity relationships of di- and trisaccharide inhibitors for Shiga-like toxin Type 1. JCS Perkin 1, 838-853, 2001.

155 Yu, H.N., Ling, C.-C. and Bundle D.R. Efficient stereoselective synthesis of 1-thio-β-mannopyranosides. JCS Perkin 1, 832-837, 2001.

154 Zhang, P. and Bundle, D.R. Synthesis of three tethered trisaccharides to probe entropy contributions in carbohydrate-protein interactions. Israel J. Chem., 40, 189-207, 2000.

153 Nitz, M., Purse B.W. and Bundle, D.R. Synthesis of a b1,2-mannopyranosyl tetrasaccharide found in the phosphomannan antigen of Candida albicans. Org. Let., 2, 2939-2942, 2000.

152 Nitz, M. and Bundle, D.R. Efficient synthesis of 3,6-dideoxy-b-D-arabinohexopyranosyl terminated LacdiNac glycan chains of the Trichinella spiralis parasite. J. Org. Chem., 65, 3064-3073, 2000.

151 Alexander, J., del Guercio, M-F., Maewal, A., Qiao, L., Filkes, J. Chesnut, R.W., Paulson, J.C., Bundle, D,R., DeFrees, S. and Sette, A. Linear PADRE T Helper Epitope and Carbohydrate B Cell Epitope Conjugates Induce Specific High Titer IgG Antibody Responses. J. Immunol. 164, 1625-1633, 2000.

150 Kitov, P.I., Sadowska, J.M., Mulvey, G., Armstrong, G.D., Ling, H., Pannu, N.S., Read, R.J. and Bundle, D.R. Shiga-like toxins neutralized by tailored multivalent carbohydrate ligands. Nature, 403, 669-672, 2000.

149 Yu, H.N., Zhang, P., Ling, C.-C. and Bundle, D.R. A practical route to 3,6-dideoxyhexoses. Tetrahedron Asymmetry, 11, 465-479, 2000.

148 Wacowich-Sgarbi, S.A. and Bundle, D.R. Constrained H-Type 2 Blood Group Trisaccharide Synthesized in a Bioactive Conformation via Intramolecular Glycosylation, J. Org. Chem., 64; 9080-9089, 1999.

147 Young, N.M., Gidney, M.A.J., Gudmundsson, B.M.E., MacKenzie, C.R., To, R., Watson, D.C. and Bundle, D.R. Molecular basis for the lack of mimicry of Brucella polysaccharide antigens by Ab2g antibodies. Molecular Immunology, 36, 339-347, 1999.

146 Seto, N.O.L., Compston, C.A., Evans, S. V., Bundle, D.R., Narang, S.A. and Palcic, M.M. Donor Specificity of Recombinant Human Blood Group A, B and Hybrid A/B Glycosyltransferases Expressed In Escherichia coli. Eur. J. Biochem. 259, 770-775, 1999.

145 Milton, M.J. and Bundle D.R. Observation of the anti- conformation of a glycosidic linkage in an antibody bound oligosaccharide. J. Am. Chem. Soc., 120:10547-10548, 1998.

144 Schriemer, D.C., Bundle, D.R., Li, L., and Hindsgaul, O. Micro-scale frontal affinity chromatography: a new method for screening of compound libraries. Angew. Chem. Int. Ed. 37: 3383-3387, 1999.

143 Otter, A., Lemieux, R.U., Ball, R.G., Venot, A.P., Hindsgaul, O., and Bundle, D.R., Crystal State and Solution Conformation of the Blood Group B Trisaccharide α-L-Fucp-(1→2)-[α -D-Galp]-(1→3)]-β-D-Galp-OCH3 Eur. J. Biochem., 259:295-303, 1999.

142 Alibes, R. and Bundle, D.R. Synthesis of tethered trisaccharides to probe inter-saccharide flexibility in carbohydrate-protein interactions. J. Org. Chem., 63: 6288-6301, 1998.

141 Bundle, D.R., Alibes, R., Nilar, S., Otter, A., Warwas, M., and Zhang, P. Thermodynamic and conformational implications of glycosidic rotamers pre-organized for binding. J. Am. Chem. Soc., 120:5317-5318, 1998.

140 Kitov, P.I., Railton, C. and Bundle, D.R. The synthesis of 16-mercaptohexadecanyl glycosides for biosensor applications. Carbohydr. Res., 307: 361-369, 1998.

139 Stangier, K., Palcic, M.M., Bundle, D.R., Hindsgaul, O., and Thiem, J. Fucosyltransferase-catalyzed formation of L-galactosylated Lewis structures. Carbohydr. Res., 305, 511-515, 1998.

138 Seto, N.O.L., Palcic, M.M., Compston, C.A., Li, H., Bundle, D.R. and Narang, S.A. Sequential interchange of four amino acids from blood group B to blood group A glycosyltransferase boosts catalytic activity and progressively modifies substrate recognition in human recombinant enzymes. J. Biol. Chem., 272: 14133-14138, 1997.

137 Ellis, L.A., McVay, C.S., Probert, M.A., Zhang, J., Bundle, D.R., and Appleton J.A. Terminal -linked tyvelose creates unique epitopes in Trichinella spiralis glycan antigens. Glycobiology, 7: 383-390, 1997)

136 Probert, M.A., Zhang, J. and Bundle D.R. Synthesis of α and βlinked Tyvelose Epitopes of the Trichinella spiralis glycan; 2-Acetamido-2-deoxy-3-O- (3,6-dideoxy-D-arabino-hexopyranosyl)-β-D-galactopyranosides. Carbohydr. Res., 296: 149-170, 1996.

135 Zhang, J., Otter A. and Bundle D.R. Synthesis and Conformational Studies of the Tyvelose Capped, Lewis-x Like Tetrasaccharide Epitope of Trichinella spiralis. Bioorgan. Med. Chem., 4: 1989-2001, 1996.

134 MacKenzie, C.R., Hirama, T., Deng, S.-J., Bundle, D.R., Narang S.A., and Young, N.M. Analysis by surface plasmon resonance of the influence of valence on the ligand binding affinity and kinetics of an anti-carbohydrate antibody. J. Biol. Chem., 271: 1527-1533, 1996.

133 Seto, N.O.L., Palcic, M.M., Hindsgaul, O., Bundle, D.R., and Narang, S.A. Expression of a recombinant human glycosyltransferase from a synthetic gene and its utilization for synthesis of the human blood group B trisaccharide. Eur. J. Biochem., 234: 323-328, 1995.

132 MacKenzie, C.R., Clark, I.D., Evans, S.V., Hill, I.E., MacManus, J.P., Dubuc, G., Bundle, D.R., Narang S.A., Young, N.M., and Szabo, A.G. Bifunctional fusion proteins consisting of a single-chain antibody and an engineered lanthanide-binding protein. Immunotechnology, 1: 139-150, 1995.

131 Lowary, T., Eichler, E., and Bundle, D.R. Synthesis of a pentasaccharide epitope for the investigation of carbohydrate-protein interactions. J. Org. Chem., 60: 7316-7327, 1995.

130 Otter A., and Bundle, D.R., Long Range ⁴J and ⁵J Including Inter-Glycosidic Correlations in Gradient-Enhanced Homonuclear COSY Experiments of Oligosaccharides. J. Mag. Reson. Ser. B, 109, 194-201, 1995.

129 Otter, A., Hindsgaul, O., and Bundle, D. R. Gradient-enhanced homonuclear 2D NMR techniques applied to oligosaccharides containing manno-hexoses provide improved correlations for protons coupled by small ³J. Carbohydr. Res., 275: 381-389, 1995.

128 Deng, S.-J., MacKenzie, C.R., Hirama, T., Brousseau, R., Lowary, T., Young, N.M., Bundle, D.R., and Narang S.A. Basis for selection of improved carbohydrate-binding single-chain antibodies from synthetic gene libraries. Proc. Natl. Acad. Sci (USA), 92: 4992-4996, 1995.

127 Evans, S.V., Sigurskjold, B.W., Jennings, H.J., Brisson, J.-R., To, R., Altman, E., Frosch, M., Weisgerber, C., Kratzin, H., Klebert, S., Vaesen, M., Bitter-Suermann, D., Rose, D.R., Young, N.M., and Bundle, D.R. The 2.8Å resolution structure, and thermodynamics of ligand binding, of an Fab specific for α (2→8)-polysialic acid. Biochemistry, 34: 6737-6744, 1995.

126 Stangier, P., Palcic, M.M., and Bundle, D.R. 2-(Dimethyloctylsilyl)ethyl lactoside: a versatile intermediate for chemical and enzymic ganglioside synthesis. Carbohydr. Res., 267: 153-159, 1995.

125 Marsden, B.J., Bundle, D.R., and Perry, M.B. Serological and structural relationships between Escherichia coli O:98 and Yersinia enterocolitica O:11,23 and O:11,24 lipopolysaccharide O-antigens. Biochem. Cell Biol., 72: 163-168, 1994.

124 Lowary, T.L., and Bundle, D.R. Nucleophile Induced Rearrangements of Thioglycosides: Formation of 6-Thio Glycosides and 1,6 Thioanhydrosugars Tetrahedron: Assymetry, 5: 2397-2404, 1994.

123 Bundle, D.R., and Eichler, E. Modulation of antibody affinity by synthetic modifications of the most exposed pyranose residue of a trisaccharide epitope. Bioorgan. Med. Chem., 2: 1221-1229, 1994.

122 Evans, S.V., Rose, D.R., To, R., Young, N.M., and Bundle, D.R. Exploring the mimicry of polysaccharide antigens by anti-idiotypic antibodies: The crystallization, molecular replacement, and refinement to 2.8Å resolution of an idiotope-anti-idiotope-Fab complex and of the unliganded-anti-idiotype Fab. J. Mol. Biol., 241: 691-705, 1994.

121 Altman, E., and Bundle, D.R. Polysaccharide Affinity Columns for Purification of Lipopolysaccharide-Specific Murine Monoclonal Antibodies. Meth. Enzymol., 242: 243-253, 1994.

120 Bundle, D.R., and Sigurskjold, B.W. Determination of Accurate Thermodynamics of Binding by Titration Microcalorimetry. Meth. Enzymol., 242: 288-305, 1994.

119 Zdanov, A., Li, Y., Bundle, D.R., Deng, S.-J., MacKenzie, C.R., Narang S.A., Young, N.M., and Cygler, M. Structure of a single-chain Fv fragment complexed with a carbohydrate antigen at 1.7Å resolution. Proc. Natl. Acad. Sci (USA), 91: 6423-6427, 1994.

118 MacKenzie, C.R., Sharma, V., Brummell, D.A., Bilous, D., Dubuc, G., Sadowska, J., Young, N.M., Bundle, D.R., and Narang S.A. Effect of C_λ-C_κ domain switching on Fab activity and yield in Escherichia coli: synthesis and expression of genes encoding two anti-carbohydrate Fabs. Bio/technology, 12: 390-395, 1994.

117 Deng, S.-J., MacKenzie, C.R., Sadowska, J., Michniewicz, J., Young, N.M., Bundle, D.R., and Narang S.A. Selection of antibody single-chain Fvs with improved carbohydrate-binding by phage display. J. Biol. Chem., 269: 9533-9538, 1994.

116 Bundle, D.R., Baumann, H., Brisson, J.-R., Gagne, S.M., Zdanov, A., and Cygler, M. The Solution Structure of a Trisaccharide-Antibody Complex: Comparison of NMR Measurements with a Crystal Structure. Biochemistry, 33: 5183-5192, 1994.

115 Bundle, D.R., Eichler, E., Gidney, M.A.J., Meldal, M., Ragauskas, A., Sigurskjold, B.W., Sinnott, B., Watson, D.C., Yaguchi, M., and Young, N.M. Molecular Recognition of a Salmonella Trisaccharide Epitope by Monoclonal Antibody SE155-4. Biochemistry, 33: 5172-5182, 1994.

114 Uhrin, D., Brisson, J.-R., and Bundle, D.R. Pseudo-3D NMR spectroscopy: Application to oligo- and polysaccharides. J. Biomolecular NMR, 3: 367-373, 1993.

113 Rose, D.R., Przybylska, M., To, R.J., Kayden, C.S., Oomen, R. P., Vorberg, E., Young, N.M., and Bundle, D.R. Crystal structure to 2.45Å resolution of a monoclonal Fab specific for the Brucella A cell wall polysaccharide antigen. Protein Science, 2: 1106-1113, 1993.

112 Auzanneau, F.-I., and Bundle, D.R. Synthesis of chlorodeoxy trisaccharides related to the Shigella flexneri Y polysaccharide. Carbohydr. Res., 247: 195-209, 1993.

111 Baumann, H., Altman, E., and Bundle, D. R. Controlled acid hydrolysis of an O-antigen fragment yields univalent heptasaccharide haptens containing one 3,6-dideoxyhexose epitope. Carbohydr. Res., 247: 347-354, 1993.

110 Auzanneau, F.-I., and Bundle, D. R. Application of thioglycoside chemistry to the synthesis of trisaccharides and deoxy-trisaccharides related to the Shigella flexneri Y polysaccharide. Can. J. Chem., 71: 534-548, 1993.

109 Vyas, M.N., Vyas, N.K. Meikle, P.J., Sinnott, B., Pinto, B.M., Bundle, D.R., and Quiocho, F.A. Preliminary crystallographic analysis of a Fab specific for the O-antigen of Shigella flexneri cell surface lipopolysaccharide with and without bound saccharides. J. Mol. Biol., 231: 133-136, 1993.

108 Brummell, D.A., Sharma, V.P., Anand, N.N., Bilous, D., Dubuc, G., Michniewicz, J., MacKenzie, C.R., Sadowska, J., Sigurskjold, B.W., Sinnott, B., Young, N.M., Bundle, D.R., Narang, S.A. Probing the combining site of an anti-carbohydrate antibody by saturation-mutagenesis: role of the heavy chain CDR3 residues. Biochemistry, 32: 1180-1187, 1993.

107 Auzanneau, F.-I., Hanna, H.R., and Bundle, D.R. The synthesis of chemically modified disaccharide derivatives of the Shigella flexneri Y polysaccharide antigen. Carbohydr. Res., 240: 161-181, 1993.

106 Hanna, H.R and Bundle, D.R. Antibody-oligosaccharide interactions: The synthesis of 2-deoxy-α-L-rhamnose containing oligosaccharide haptens related to Shigella flexneri variant Y antigen. Can. J. Chem., 71: 125-134, 1993.

105 Reimer, K.B., Gidney, M.A.J., Bundle, D.R., and Pinto, B.M. Immunochemical characterization of polyclonal and monoclonal streptococcus group A antibodies by chemically defined glycoconjugates and synthetic oligosaccharides. Carbohydr. Res., 232: 131-142, 1992.

104 Sigurskjold, B., and Bundle, D.R. Thermodynamics of oligosaccharide binding to a monoclonal antibody specific for a Salmonella O-antigen point to hydrophobic interactions in the binding site. J. Biol. Chem., 267: 8371-8376, 1992.

103 Narang, S.A., Brummell, D.A., Sharma, V., Bilous, D., Dubuc, G., MacKenzie, C.R., Michniewicz, J., Sadowska, J., Anand, N.N., Young, N.M., and Bundle, D.R. Scanning of key residues in antibody binding sites by two saturation-mutagenesis approaches. Nucleic Acid Res., 24: 173-179, 1991.

102 Anand, N.N., Mandal, S., MacKenzie, C.R., Sadowska, J., Sigurskjold, B., Young, N.M., Bundle, D.R., and Narang, S.A. Bacterial Expression and Secretion of Various Single-Chain Fv Genes Encoding Proteins Specific for a Salmonella Serotype B O-Antigen. J. Biol. Chem., 266: 21874-21879, 1991.

101 Cygler, M., Rose, D.R., and Bundle, D.R. Recognition of a cell surface oligosaccharide epitope of pathogenic Salmonella by an antibody Fab fragment. Science, 253: 442-446, 1991.

100 Anand, N.N., Dubuc, G., Phipps, J., MacKenzie, C.R., Sadowska, J., Young, N.M., Bundle, D.R., and Narang, S.A. Synthesis and expression in Escherichia coli of cistronic DNA encoding an antibody fragment specific for a Salmonella serotype B O-antigen. Gene, 100: 39-44, 1991.

99 Kihlberg, J., and Bundle, D.R. The synthesis of antibody binding site probes: A exasaccharide and two pentasaccharides related to the Brucella A antigen prepared by in situ activation of thioglycosides with bromine. Carbohydr. Res., 216: 67-78, 1991.

98 Eichler, E., Kihlberg, J., and Bundle, D.R. Access to fluorescent probes via allyl glycosides; the synthesis of a Brucella trisaccharide epitope linked to a coumarin. Glycoconjugate J., 8: 69-74, 1991.

97 Auzanneau, F.-I., and Bundle, D.R. Incidence and avoidance of stereospecific 1,2-thioethyl migration during the synthesis of ethyl 1-thio-α-L-rhamnopyranoside 2,3-orthoester. Carbohydr. Res., 212: 13-24, 1991.

96 Oomen, R., Young, N.M., and Bundle, D.R. Molecular modeling of antibody: antigen complexes between the Brucella abortus O-chain polysaccharide and a specific monoclonal antibody. Protein Engineering, 4: 427-433, 1991.

95 Sigurskjold, B.W., Altman, E., and Bundle, D.R. Sensitive titration microcalorimetric study of the binding of Salmonella O-antigenic oligosaccharide by a monoclonal antibody. Eur. J. Biochem., 197: 239-246, 1991.

94 Kihlberg, J., Eichler, E., and Bundle, D.R. The design and synthesis of antibody binding site probes: three pentasaccharide analogues of the Brucella A antigen prepared by in situ activation of thioglycosides with bromine. Carbohydr. Res., 211: 59-75, 1991

93 Rose, D.R., Cygler, M., To, R.J., Przybylska, M., Sinnott, B., and Bundle, D.R. Preliminary crystal structure determination of an Fab specific for a Salmonella O-polysaccharide antigen. J. Mol. Biol., 215: 489-492, 1990.

92 Meikle, P.J., Young, N.M., and Bundle, D.R. O-antigen biotin conjugates: Preparation and use in direct competitive enzyme immunoassays. J. Immunol. Meth., 132: 255-261, 1990.

91 Meikle, P.J., and Bundle, D.R. Preparation of polysaccharide enzyme conjugates for competitive binding assays. Glycoconjugate J., 7: 207-218, 1990.

90 Vorberg, E., and Bundle, D.R. Carbohydrate-enzyme conjugates for competitive EIA. J. Immunol. Meth., 132: 81-89, 1990.

89 Beynon, L.M., Bundle, D.R., and Perry, M.B. The structure of the antigenic lipopolysaccharide O-chain produced by Escherichia hermanii ATCC 33650 and 33652. Can. J. Chem., 68: 1456-1466, 1990.

88 Anand, N.N., Dubuc, G., Mandal, S., Phipps, J., Gidney, M.A.J., Sinnott, B., Young, N.M., MacKenzie, C.R., Bundle, D.R., and Narang, S.A. Synthesis and expression in Escherichia coli of DNA encoding the murine 1 chain of a monoclonal antibody specific for Salmonella serotype B O-antigen. Protein Engineering, 3: 541-546, 1990.

87 Kihlberg, J.O., Leigh, D.A., and Bundle, D.R. The in situ activation of thioglycosides with bromine: An improved glycosylation method. J. Org. Chem., 55: 2860-2863, 1990.

86 Peters, T., Brisson, J.-R., and Bundle, D.R. Conformational analysis of key disaccharide components of Brucella A and M antigens. Can. J. Chem., 68: 979-988, 1990.

85 Perry, M.B., and Bundle, D.R. Antigenic relationships in the lipopolysaccharides of strains of Escherichia hermannii with Escherichia coli 0157:H7, Brucella melitensis and Brucella abortus. Infect. Immun. 58: 1391-1395, 1990.

84 Pinto, B.M., Reimer, K.B., Morissette, D.G., and Bundle, D.R. Synthesis and 2D-n.m.r. analysis of a pentasaccharide glycoside of the biological repeating units of Shigella flexneri variant Y polysaccharide and the preparation of a synthetic antigen. Carbohydr. Res., 196: 156-166, 1990.

83 Pinto, B.M., Reimer, K.B., Morissette, D.G., and Bundle, D.R. Oligosaccharides corresponding to biological repeating units of Shigella flexneri variant Y polysaccharide: Part III. Synthesis and 2D NMR analysis of a heptasaccharide hapten. J. Chem. Soc. Perkin I, 293-299, 1990.

82 Meikle, P.J., Perry, M.B., Cherwonogrodzky, J.W., and Bundle, D.R. Fine structure of A and M antigens from Brucella biovars. Infect. Immun., 57: 2820-2828, 1989.

81 Bundle, D.R., Cherwonogrodzky, J.W., Gidney, M.A.J., Meikle, P.J., Perry, M.B., and Peters, T. Definition of Brucella A and M epitopes by monoclonal typing reagents and synthetic oligosaccharides. Infect. Immun., 57: 2829-2836, 1989.

80 Nielsen, K., Cherwonogrodzky, J.W., Duncan, J.R., and Bundle, D.R. Enzyme-linked immunosorbent assay for differentiation of the antibody response of cattle naturally infected with Brucella abortus or vaccinated with strain 19. Am. J. Vet. Res., 50: 5-9, 1989.

79 Pinto, B.M., Reimer, K.B., Morissette, D.G., and Bundle, D.R. Oligosaccharides corresponding to biological repeating units of Shigella flexneri variant Y polysaccharide. Synthesis and two-dimensional NMR analysis of a hexasaccharide hapten. J. Org. Chem., 54: 2650-2656, 1989.

78 Peters, T., and Bundle, D.R. Block synthesis of two pentasaccharide determinants of the Brucella M antigen using thioglycoside methodologies. Can. J. Chem., 67:497-502, 1989.

77 Peters, T., and Bundle. D.R. Synthetic antigenic determinants of the Brucella A polysaccharide; a disaccharide thioglycoside for block synthesis of pentasaccharide and lower homologues of α1,2-linked 4,6-dideoxy-4-formamido-α-D-mannose. Can. J. Chem., 67: 491-496, 1989.

76 Bundle, D.R. Antibody combining sites and oligosaccharide determinants studied by competitive binding, sequencing and X-ray crystallography. Pure and Applied Chem., 61: 1171-1180, 1989.

75 Zygmunt, M.S., Dubray, G., Bundle, D.R., and Perry, M.B. Purified native haptens of Brucella abortus B19 and B. melitensis 16 M reveal the lipopolysaccharide origin of the antigens. Ann. Inst. Pasteur/Microbiol., 139: 421-433, 1988.

74 Kulakowska, M., Lugowski, C., Romanowska, E., and Bundle, D.R. The comparison of monoclonal-antibodies specific for 2 general epitopes located on citrobacter-036 lipopolysaccharide. Carbohydr. Res., 178: 233-241, 1988.

73 Perry, M.B., Bundle, D.R., Gidney, M. A.J., and Lior, H. Identification of Escherichia coli serotype 0157 strains by using monoconal antibody. J. Clin. Microbiol., 26: 2391-2394, 1988.

72 Todd, E.C.D., Szabo, R.A., Peterkin, P., Sharpe, A.N, Parrington, L., Bundle, D.R., Gidney, M.A.J., and Perry, M.B. Rapid hydrophobic grid membrane filter -enzyme labelled antibody procedure for identification and enumeration of Escherichia coli 0157 in foods. Applied and Environmental Microbiology, 54: 2536-2540, 1988.

71 Kramer, J.K.G., Sauer, F.D., and Bundle, D.R. The presence of tightly bound Na⁺ or K⁺ in glycolipids in Methanobacterium thermoautotrophicum. Biochim. Biophys. Acta., 961: 285-292, 1988.

70 Bundle, D.R., Cherwonogrodzky, J.W., and Perry, M.B. Characterization of Brucella polysaccharide B. Infect. Immun., 56: 1101-1106, 1988.

69 Bundle, D.R., Gerken, M., and Peters, T. Synthesis of antigenic determinants of the Brucella A antigen utilizing methyl 4-azido-4,6-dideoxy-α-D-mannopyranoside efficiently derived from D-mannose. Carbohydr. Res., 174: 239-251, 1988.

68 Peters, T., and Bundle, D.R. Synthesis of 4,6-dideoxy-4-formamido-α-D- mannose containing tri- tetra- and pentasaccharides, antigenic determinants of the Brucella A and M antigens. J. Chem. Soc. Chem. Comm., 1648-1650, 1987.

67 Gerken, M., and Bundle, D.R. Synthesis of immunologically active oligosaccharide determinants of the Brucella A antigen: utilization of intermediates derived from methyl 4-azido-4,6-dideoxy-α-D-mannopyranoside. Tet. Lett., 28:5067-5070, 1987.

66 Bundle, D.R., Cherwonogrodzky, J.W., and Perry, M.B. Structural elucidation of the Brucella melitensis M antigen by high resolution NMR at 500 MHz. Biochemistry, 26:8717-8726, 1987.

65 Di Fabio, J.L., Perry, M.B., and Bundle, D.R. Analysis of the lipopolysaccharide of Pseudomonas maltophilia 555. Biochem. Cell. Biol., 65: 968-977, 1987.

64 Altman, E., Brisson, J.-R., Bundle, D.R., and Perry, M.B. Structural studies of the O-chain of the phenol-phase soluble lipopolysaccharide from Haemophilus pleuropneumoniae serotype 2. Biochem. Cell Biol., 65: 876-889, 1987.

63 Cherwonogrodzky, J.W., Perry, M.B., and Bundle, D.R. Identification of the A and M antigens of Brucella as the O-polysaccharides of smooth lipopolysaccharides. Can. J. Microbiol., 33: 979-981, 1987.

62 Carlin, N.I.A., Bundle, D.R., and Lindberg, A.A. Characterization of five Shigella flexneri variant Y - specific monoclonal antibodies using defined saccharides and glycoconjugate antigens. J. Immunol., 138: 4419-4427, 1987.

61 Bundle, D.R., Cherwonogrodzky, J.W., and Perry, M.B. The structure of the lipopolysaccharide O-chain (M antigen) and polysaccharide B produced by Brucella melitensis 16M. FEBS Letters, 216: 261-264, 1987.

60 Sugden, E.A., Samagh, B.S., Bundle, D.R., and Duncan, J.R. Lipoarabinomannan and lipid-free arabinomannan antigens of Mycobacterium paratuberculosis. Infect. Immun.. 55: 762-770, 1987.

59 Bundle, D.R., Cherwonogrodzky, J.W., Caroff, M., and Perry, M.B. The lipopolysaccharides of Brucella abortus and B. melitensis. Ann. Inst. Pasteur/Microbiol., 138: 92-98, 1987.

58 Pinto, B.M., Morrisette, D.G., and Bundle, D.R. Synthesis of oligosaccharides corresponding to biological repeating units of Shigella flexneri Y polysaccharide. Part 1. Overall strategy, synthesis of a key trisaccharide intermediate, and synthesis of a pentasaccharide. J. Chem. Soc. Perkin I, 9-14, 1987.

57 Carlin, N.I.A., Gidney, M.A.J., Lindberg, A.A., and Bundle, D.R. Characterization of Shigella flexneri specific murine monoclonal antibodies by chemically defined glycoconjugates. J. Immunol., 137: 2361-2366, 1986.

56 Perry, M.B., Bundle, D.R., MacLean, L., Perry, J.A., and Griffith, D.W. The structure of the antigenic lipopolysaccharide O-chains produced by Salmonella urbana and Salmonella godesberg. Carbohydr. Res., 156: 107-122, 1986.

55 Bundle, D.R., Gerken, M., and Perry, M.B. Two dimensional NMR at 500 MHz: The structural elucidation of a Salmonella serogroup N polysaccharide antigen. Can. J. Chem., 64: 255-264, 1986.

54 Lemieux, R.U., Venot, A.P., Spohr, U., Bird, P., Mandal, G., Morishima, N., Hindsgaul, O., and Bundle, D.R. Molecular recognition. V. The binding of the B human blood group determinant by hybridoma monoclonal antibodies. Can. J. Chem., 63:2664-2668, 1985.

53 Emmrich, F., Bundle, D.R., van der Zee, J., Out, T., Zenke, G., and Eichmann, K. Two human IgM myeloma proteins with unusual specificities for streptococcal carbohydrate-associated epitopes. Scand. J. Immunol., 21: 119-126, 1985.

52 Wessel, H.P., and Bundle, D.R. Strategies for the synthesis of branched oligosaccharides of the Shigella flexneri 5a, 5b and variant X serogroups employing a multifunctional rhamnose precursor. J. Chem. Soc., Perkin I, 2251-2260, 1985.

51 Wessel, H.P., Iversen, T., and Bundle, D.R. Acid-catalysed benzylation and allylation by alkyl trichloroacetimidates. J. Chem. Soc., Perkin I, 2247-2250, 1985.

50 Gidney, M.A.J., Bundle, D.R., Godard, A., and Griffiths, B.W. Development and characterization of monoclonal antibodies to pregnancy-specific α1-glycoprotein. Can. J. Biochem., 63 (7): 737-742, 1985.

49 Birnbaum, G.I., and Bundle, D.R. Conformation of methyl 3,6-dideoxy-α-D-arabino-hexopyranoside, the immunodominant sugar of Salmonella serogroup D₁: Crystal structure, ¹H NMR analysis and semi-empirical calculations. Can. J. Chem., 63: 739-744, 1985.

48 Pinto, B.M., and Bundle, D.R. Antigenic determinant of Salmonella serogroup B. Synthesis of a trisaccharide glycoside for use as an artificial antigen. Carbohydr. Res., 133: 333-338, 1984.

47 Bundle, D.R., Gidney, M.A.J., Perry, M.B., Duncan, J.R., and Cherwonogrodzky, J.W. Serological confirmation of Brucella abortus and Yersinia enterocolitica 0:9 O-antigens by monoclonal antibodies. Infect. Immun., 46: 389-393, 1984.

46 Caroff, M., Bundle, D.R., Perry, M.B., Cherwonogrodsky,J.W., and Duncan, J.R. Antigenic S-type lipopolysaccharide of Brucella abortus 1119-3. Infect. Immun., 46: 384-388, 1984.

45 Bock, K., Meldal, M., Bundle, D.R., Iversen, T., Pinto, B.M., Garegg, P.J., Kvanström, I., Norberg, T., Lindberg, A.A., and Svenson, S.B. The conformation of Salmonella O-antigenic oligosaccharides of serogroups A, B and D₁ inferred from ¹H and ¹³C nuclear magnetic resonance spectroscopy. Carbohydr. Res., 130: 35-53, 1984.

44 Bock, K., Meldal, M., Bundle, D.R., Iversen, T., Garegg, P.J., Norberg, T., Lindberg, A.A., and Svenson, S.B. The conformation of Salmonella O-antigenic polysaccharide chains of serogroups A, B and D₁ predicted by semi-empirical hard sphere (HSEA) calculations. Carbohydr. Res., 130: 23-34, 1984.

43 Carlin, N. I. A., Lindberg, A. A., Bock, K., and Bundle, D. R. The Shigella flexneri O-antigenic polysaccharide chain: Nature of the biological repeating unit. Eur. J. Biochem., 139: 189-194, 1984.

42 Shearman, P.J., Bundle, D.R., Romanowska, E., Lugowski, C., and Bogulska, M. Characterization of anti-Citrobacter 036-specific polysaccharide monoclonal antibodies. Can. J. Microbiol., 30: 91-97, 1984.

41 Caroff, M., Bundle, D. R., and Perry, M. B. Structure of the O-chain of the phenol-phase soluble cellular lipopolysaccharide of Yersinia enterocolitica serotype 0:9. Eur. J. Biochem., 139: 195-200, 1984.

40 Wessel, H.P., Iversen, T., and Bundle, D.R. Synthesis of the trisaccharide moiety of gangliotriosylceramide, Asialo GM2. Carbohydr. Res., 130: 5-21, 1984.

39 Wessel, H.P., and Bundle, D.R. Artificial carbohydrate antigens: A block synthesis of a linear tetrasaccharide repeating unit of the Shigella flexneri variant Y polysaccharide. Carbohydr. Res., 124: 301-311, 1983.

38 Pinto, B.M., and Bundle, D.R. Preparation of glycoconjugates for use as artificial antigens: A simplified procedure. Carbohydr. Res., 124: 313-318, 1983.

37 Kenne, L., Lindberg, B., Soderholm, E., Bundle, D.R., and Griffith, D.W. Structural studies of the O-antigens from Salmonella greenside and Salmonella adelaide. Carbohydr. Res., 111: 289-296, 1983.

36 Bhattacharjee, A.K., Bennett, J.E., Bundle, D.R., and Glaudemans, C.P.J. Anticryptococcal type D antibodies raised in rabbits. Mol. Immunol., 20: 351-359, 1983.

35 Bundle, D.R., Gidney, M.A.J., Kassam, N., and Rahman, A.F.R. Hybridomas specific for carbohydrates; synthetic human blood-group antigens for the production, selection and characterization of monoclonal typing reagents. J.Immunol., 129: 678-682, 1982.

34 Neurohr, K.J., Bundle, D.R., Young, N.M., and Mantsch, H.H. Binding of disaccharides by peanut agglutinin as studied by ultraviolet difference spectroscopy. Eur. J. Biochem., 123: 305-310, 1982.

33 Iversen, T., and Bundle, D.R. Synthesis of the colitose determinant of Escherichia coli 0111 and 3,6-di-O-(α-D-galactopyranosyl)-α-D-glucopyranoside. Can. J. Chem., 60: 299-303, 1982.

32 Iversen, T., and Bundle, D.R. Antigenic Determinants of Salmonella A and D₁ synthesis of trisaccharide glycosides for use as artificial antigens. Carbohydr. Res., 103: 29-?, 1982.

31 Bock, K., Josephson, S., and Bundle, D.R. Lipopolysaccharide solution conformation: Antigen shape inferred from high resolution ¹H and ¹³C nuclear magnetic resonance spectroscopy and hard-sphere calculations. J. Chem. Soc., Perkin II, 59-70, 1982.

30 Perry, M.B., Bundle, D.R. Daoust, V., and Carlo D.J. The specific capsular polysaccharide of Streptococcus pneumoniae type 15F. Mol. Immunol., 19:235-246, 1982.

29 Neurohr, K.J., Mantsch, H.H., Young, N.M., and Bundle, D.R. Carbon-13 nuclear magnetic resonance studies on lectin-carbohydrate interactions: Binding of specifically ¹³C-labelled methyl β-D-lactoside to peanut agglutinin. Biochemistry, 21:498-503, 1982.

28 Iversen, T., and Bundle. D.R. A direct and efficient synthesis of β-L-rhamnopyranosides. J. Org. Chem., 46: 5389-?, 1981.

27 Iversen, T., and Bundle, D.R. Benzyl trichloroacetimidate, a versatile reagent for acid-catalyzed benzylation of hydroxy-groups. Chem. Comm., 1240-1241, 1981.

26 Iversen, T., Josephson, S., and Bundle, D.R. The synthesis of streptococcal groups A,C and variant-A antigenic determinants. J. Chem. Soc, Perkin I. 2379-2385, 1981.

25 Bundle, D.R., and Josephson, S. Chlorosulphation of amino sugars: Synthesis of methyl 2-acetamido-4-amino-2,4,6-trideoxy-α-D-glucopyranoside (bacillosamine) from a D-glucosamine derivative. Can. J. Chem., 58: 2679-2685, 1980.

24 Iversen, T., and Bundle, D.R. A new and efficient synthesis of β-L-rhamnopyranosides. Carbohydr. Res., 84: C13-C15, 1980.

23 Josephson, S., and Bundle, D.R. Artificial carbohydrate antigens: The synthesis of rhamnose trisaccharide and disaccharide haptens common to Shigella flexneri O-antigens. J. Chem. Soc., Perkin I. 297-301, 1980.

22 Bundle, D.R., and Josephson, S. Artificial carbohydrate antigens: The synthesis of tetra-saccharide hapten, a Shigella flexneri O-antigen repeating unit. Carbohydr. Res., 80: 75-85, 1980.

21 Josephson, S., and Bundle, D.R. Artificial carbohydrate antigens: The synthesis of the tetrasaccharide repeating unit of Shigella flexneri O-antigen. Can. J. Chem., 57:3073-3079, 1979.

20 Unemura, J., Birnbaum, G.I., Bundle, D.R., Murphy, W.F., Bernstein, H.J., and Mantsch, H.H. The correlation between O-H stretching frequencies and hydrogen bond distances in a crystalline sugar monohydrate. Can. J. Chem., 57: 2640-2645, 1979.

19 Banoub, J., and Bundle, D.R. 1,2-orthoacetate intermediates in silver trifluoro-methanesulphonate promoted Koenigs-Knorr synthesis of disaccharide glycosides. Can. J. Chem., 57: 2091-2097, 1979.

18 Banoub, J., and Bundle, D.R. Stannic tetrachloride catalysed glycosylation of 8-ethoxy-carbonyloctanol by cellobiose, lactose and maltose octacetates; synthesis of  and  glycosidic linkages. Can. J. Chem., 57: 2085-2090, 1979.

17 Bundle, D.R. Antibody to an artificial disaccharide antigen cross-reactive with Neisseria gonorrhoeae lipopolysaccharide. Can. J. Biochem., 57: 367-371, 1979.

16 Bundle, D.R. Displacement of sugar chlorosulphates by bromide, azide and acetate; a facile synthesis of methyl, 3,6-dideoxy-β-D-ribo-hexopyranoside. J. Chem. Soc., Perkin I, 2751-2755, 1979.

15 Bundle, D.R., and Josephson, S. Artificial carbohydrate antigens: The synthesis and conformation of a Shigella flexneri trisaccharide hapten. J. Chem. Soc., Perkin I, 2736-?, 1979.

14 Bundle, D.R., and Josephson, S. Artificial carbohydrate antigen: Synthesis of rhamnose disaccarides common to Shigella flexneri O-antigen determinants. Can. J. Chem., 57: 662-668, 1979.

13 Birnbaum, G.I., and Bundle, D.R. Solution conformation and crystal structure of methyl 3,6-dideoxy-β-D-ribo-hexopyranoside, an immunodominant sugar of O-antigens. Biochim. Biophys. Acta, 582: 515-524, 1979.

12 Bundle, D.R., and Josephson, S. A facile synthesis of methyl 3,6-dideoxy-L-xylo-hexopyranoside (colitose). Can. J. Chem., 56: 2686-2690, 1978.

11 Lemieux, R.U., Boullanger, P.A., Bundle, D.R., Baker, D.A., and Venot, A. Binding studies of β-D-galactopyranosyl antibodies. Intramolecular hydrogen bonding effects. Nouveau. J. Chimie, 2: 321, 1978

10 Jennings, H.J., Bhattacharjee, A.K., Bundle, D.R., Kenny, C.P., Martin, A., and Smith, I.C.P. Structures of the capsular polysaccharides of Neisseria meningitidis as determined by C-13 nuclear magnetic resonance spectroscopy. J. Infectious Diseases, 136: S78-S83, 1977.

9 Lemieux, R.U., Baker, D.A., and Bundle, D.R. A methodology for the production of carbohydrate-specific antibody. Can. J. Biochem., 55: 507-512, 1977.

8 Bundle, D.R., and Lemieux, R.U. Determination of anomeric configuration by NMR. Methods in Carbohydr. Chem., 7: 79-86, 1976.

7 Lemieux, R.U., Bundle, D.R., and Baker, D.A. The properties of a synthetic antigen related to the human blood group Lewis-a. J. Am. Chem. Soc., 97: 4076-4083, 1975.

6 Bundle, D.R., and Jennings, H.J. The synthesis of 2-acetamido-2-deoxy-α-D-glucopyranose 4-phosphate. Can. J. Biochem., 52: 723-725, 1974.

5 Bundle, D.R., Jennings, H.J., and Kenny, C.P. Studies on the group-specific polysaccharide of Neisseria meningitidis serogroup X and an improved procedure for its isolation. J. Biol. Chem., 249: 4797-4801, 1974.

4 Bundle, D.R., Smith I.C.P., and Jennings, H.J. Determination of the structure and conformation of bacterial polysaccharides by carbon-13 nuclear magnetic resonance. J. Biol. Chem., 249: 2275-2281, 1974.

3 Bundle, D.R., Jennings, H.J., and Smith, I.C.P. The carbon-13 nuclear magnetic resonance spectra of 2-acetamido-2-deoxy-D-hexoses and some specifically deuterated, O-acetylated, and phosphorylated derivatives. Can. J. Chem., 51: 3812-3819, 1973.

2 Bundle, D.R., Jennings, H.J., and Kenny, C.P. An improved procedure for the isolation of meningococcal, polysaccharide antigens, and the structural determination of the antigen from serogroup X. Carbohydr. Res., 26: 268-270, 1973.

1 Bundle, D.R., and Shaw, N. Synthesis of 2-acetamido-6-O-(2-acetamido-2- deoxy-β-D-glucopyranosyl)-2-deoxy-D-glucopyranose. Carbohydr. Res., 21: 211-, 1972.

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